This is the first career ATP singles title for the second-seeded Tsonga, who avenged his Australian Open final defeat to Novak Djokovic with a 7-6 (7/4) 6-4 victory.
23-year-old Tsonga, who is ranked 20 in the world, made his return from knee surgery at the US Open after a three month absence.
"I feel great, it's got to be one of the best moments of my life," he said.
Novak Djokovic, ranked No. 3 in the world, looked sluggish and ended the match by lobbing Tsonga's serve long.
Tsonga pockets $94,000 for winning the Thailand Open title, while Djokovic takes home $51,000.
